Benzothiazepines



United States Patent 3,361,750 BENZOTI-HAZEPINES John Krapcho, Somerset, N.J., assiguor, by mesne assignments, to E. R. Squibb & Sons, Inc., New York, N.Y., a corporation of Delaware No Drawing. Filed Mar. 21, 1963, Ser. No. 266,824 Claims. (Cl. 260-268) This invention relates to new chemical compounds having valuable therapeutic properties and processes and intermediates for the preparation thereof.

The therapeutically active compounds of this invention are bases of the general Formula I:

and the acid-addition salts thereof, wherein X is hydrogen, lower alkyl, lower alkoxy, nitro, halo or trifluoromethyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, or an X-substituted phenyl lower alkyl; A is lower alkylene (perferably methylene and ethylene); and NB is a basic nitrogen-containing radical of less than twelve carbon atoms. Among the suitable radicals represented by the symbol NB are: amino; (lower alkyl)amino; di(lower alkyl)amino; (hydroxyl lower alkyl)amino; di- (hydroXy lower alkyl)amino; phenyl (lower alkyl) amino; N (lower alkyl) N phenylflower alkyl)arnino; and saturated 5 to 7 membered monocyclic N heterocyclic radicals of less than twelve carbon atoms, as exemplified by piperidino; (lower alkyl) piperidino; (lower alkoxy)piperidino; homopiperidine; pyrrolidino; (lower alkyl) pyrrolidino; di(lower alkyl)pyrro1idino; (lower alkoxy)pyrrolidino; morpholino; (lower alkyl)morpholino; di(lower alkyl)morpholino; (lower alkoxy)morpholino; thiamorpholino; (lower alkyl)thiamorpholino; di- (lower alkyl)thiamorpholino; (lower alkoxy)thiarnorpholino; piperazino; (lower alkyl)piperazino (e.g., N methylipiperazino); di(lower alkyl) piperazino; (lower alkoxy) piperazino; N (hydroxy lower)piperazino; N (lower alkanoyloxy lower alkyl)piperazino; and homopiperazino. The terms lower alkyl, and lower alkoxy, and lower alkylene as employed herein, include both straight and branched chain radicals of less than eight carbon atoms. The particularly preferred compounds are those wherein X is hydrogen or chloro; R is hydrogen; R is lower alkyl; A is methylene or ethylene; and NB is di(lower alkyl)amino, piperidino or N -methylpiperazino.

As to the salts, those coming within the purview of this invention include the acid-addition salts, particularly the non-toxic acid-addition salts. Acids useful for preparing these acid-addition salts include, inter alia, inorganic acids, such as the hydrohalic acids (e.g., hydrochloric and hydrobromic acid), sulfuric acid, nitric acid, boric acid and phosphoric acid, and organic acids, such as oxalic, tartaric, citric, acetic, succinic, pamoic and maleic acid.

The compounds of this invention and the acid-addition salts thereof are therapeutically active compounds which posses antispasmodic activity and hence are utilized in the treatment of Parkinsonism. Thus, the compounds of this invention can be administered perorally, the dosage for such treatment being adjusted for the activity of the particular compound employed.

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The compounds of this invention can be prepared by the process of this invention, the first step of which comprises reducing a compound of the general Formula II:

SCHR1 X CHR Nn-o=o wherein X, R and R are as hereinbefore defined. Compounds II can be prepared as disclosed in US. Patent No. 3,075,967, granted Jan. 29, 1963. The reduction is accomplished by treating Compounds II with a reducing agent, such as lithium aluminum hydride, whereby the intermediates of the general Formula III are formed:

(III) wherein X, R and R are as herebefore defined.

Suitable starting compounds of the Formula II include: 2,3 dihydro 1,5 benzothiazepin 4 one; 2,3 dihydro 2 (lower alkyl) 1,5 benzothiazepin 4 ones, such as 2,3 dihydro 2 methyl 1,5 benzothiazepin 4 one, 2,3 dihydro 2 ethyl 1,5 benzothiazepin 4 one and 2,3 dihydro 2 n hexyl 1,5 benzothiazepin 4 one; 2,3 dihydro 2 (X substituted penyl lower alkyl) 1,5 benzothiazepin 4 ones, such as 2,3 dihydro 2 benzyl 1,5 benzothiazepin 4 one, 2,3 dihydro 2 phenethyl 1,5 benzothiazepin 4 one and aromatically substituted lower alkyl, lower alkoxy, nitro, halo, and trifiuoromethyl derivatives thereof; 2,3 dihydro 3 (lower alkyl) 1,5 benzothiazepin 4 ones, such as 2,3 dihydro 3 methyl 1,5 benzothiazepin 4 one, 2,3 dihydro 3 ethyl 1,5 benzothiazepin 4 one and 2,3 dihydro 3 n butyl 1,5 benzothiazepin 4 one; 2,3 dihydro 2,3 di(lower alkyl) 1,5 benzothiazepin 4 ones, such as 2,3 dihydro 2,3 -dimethyl 1,5 benzothiazepin 4 one and 2,3 dihydro 2 methyl 3 ethyl 1,5 benzothiazepin 4 one; and 2,3 dihydro 2 (X substituted phenyl lower alkyl) 3 (lower alkyl) 1,5 benzothiazepin 4 ones, such as 2,3 dihydro 2 benzyl 3 methyl 1,5 benzothiazepin 4 one, and aromatically substituted lower alkyl, lower alkoxy, nitro, halo and trifluoromethyl derivatives thereof.

Compounds III are then condensed with a chloro(lower alkanoyl) chloride of the formula: ClA-COCl, wherein A is as hereinbefore defined, to yield new intermediates of this invention of the general Formula IV.

SCHR1 X CHR \NCH2 wherein X, R, R and A are as hereinbefore defined. The reaction is preferably conducted in an organic solvent for the reactants in the presence of tertiary organic base, such as triethylamine, at an elevated temperature, such as the reflux temperature of the mixture.

Compounds IV are then reacted with a base of the formula: HNB, wherein NB is as hereinbefore defined to yield the final products of this invention.

'3 a l The following examples illustrate the invention (all temperatures being in centigrade):

EXAMPLE 1 2,3,4,5tetrahydro-2 methyl-S-piperidinoacelyl-l ,5- ber'izothiazepine hydrochloride (A) Preparation of 2,3,4,5-tetrahydro-2-methyl- 1,5-benzothiazepine A slurry of 19.0 g. of lithiumaluminum hydride in 2.5 1. of anhydrous ether is treated portionwise with 96.5

g. of 2,3 dihydro 2 methyl 1,5 benzothiazin 4 one. After stirring for 40 hours at room temperature, the mixture is cooled and treated with 32 ml. of ethyl acetate, followed by dropwise addition of 64 ml. of water and then a solution of 16 g. of sodium hydroxide in 200 ml. of water. The organic phase is filtered from the inorganic salt and the filtrate dried over magnesium sulfate. After evaporation of the solvent, the residue is fractionated to give about 77.6 g. of product; B.P. about 110-111 (0.3

mm.). This material solidifies and melts at about 45-47 (B) Preparation of 5-chloroacetyl -2,3,4,5-tetrahydro- Z-methyl-1,5-benzothiazepine A solution of 138.0 g. of material from part (A), 78.0 g. of triethylamine and '1 l. of benzene is cooled, stirred V and treated with a solution of 87 g. of chloroacetyl chlor (C) Preparation of 2,3,4,S-tetrahydro-Z-methyl-S- piperidinoacetyl-1,5-benzothiazepine A mixture of 42 g. of material from part (B), 43.0 g. of piperidine and 200 ml. of xylene is refluxed for eight hours, cooled and treated with 100 ml. of water and then a solution of 35 ml. of cone. hydrochloric acid in 200 ml. of water. The aqueous phase is cooled and treated with a solution of 25 g. of sodium hydroxide in 100 ml. of Water. The liberated base is extracted with ether and the extract dried over magnesium sulfate. The solvent is evaporated and the residue fractionated to give about 45 g. of pale yellow liquid; B.P. about 165-167(0.1 mm). This distillate rapidly solidifies, M.P. about 106-107.

(D) Preparation of 2,3,4,S-tetrahydro-Z-methyl-S- piperidinoactyl-1,5-benzothiazepine, hydrochloride A solution of 44.5 g. of material from part (C) in 50 ml. of ethanol is treated With an equivalent of hydrogen chloride in 27 ml. of ethanol. The resulting solution is diluted to 800 ml. with ether to give about 43 g. of product, M.P. about 186-188. After crystallization from 150 ml. of acetonitrile-SOO ml. of ether, the product melts at about 187-189".

EXAMPLE 2 2,3,4,5-tezrahydr-2-m ethyl-- (4 -methyl-1 -piperazinyl acetyl] -1,5-benzothiazepine, hydrochloride Interaction of 51.0 g. of material from part (B) of Example 1 with 50 g. of N-methylpiperazine in 300 ml. of xylene is carried out in the same manner as described in part (C) of Example 1 to give about 56 g. of nearly colorless liquid; B.P. about 175-176 (0.1 mm). The distillate rapidly solidifies, M.P. about 118-120. This base (50.7 g.) is dissolved in '40 ml. of absolute alcohol and treated with one equivalent of hydrogen chloride in 30 ml. of absolute alcohol. The solution is diluted with 700 4 ml. of ether to give about 56.5 g. of product; M.P. about -163. After crystallization from 200 ml. of acetonitrile-400 ml. of ether, the colorless product weighs about 50.0 g., M.P. about 163-165.

EXAMPLE 3 S-dimethylaminoacetyl-2,3,4,5-tetrahydro-2-methyl- 1,5-benz0thiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of dimethylamine for the piperidine in part (C), 5 dimethylaminoacetyl 2,3,4,5 tetrahydro 2 methyl 1,5 benzothiazepine, hydrochloride is obtained.

EXAMPLE 4 V 5 -pyrrolidinoacetyl-2 ,3,4, 5 -tetrahydro-2-methyl-I ,5 benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of pyrrolidine for the piperidine Following the procedure of Example 1 but substituting an equivalent amount of N-methyl-N-phenethylamine for the piperidine in part (C), S-(N-methyl-N-phenethylaminoacetyl) 2,3,4,5 tetrahydro-Z-methyl-1,5-benzethiazepine, hydrochloride is obtained.

EXAMPLE 6 5-diethylaminoacetyl-2,3,4,5-tetrahydro-2-methyl-1,5- benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of diethylamine for the piperidine in part (C), 'S-diethylaminbacetyl 2,3,4,5-tetrahydro-2-methyl-1,5-benzothiazepine, hydrochloride is obtained.

EXAMPLE 8 5 (3-piperidinopropionyl -2,3,4,5 -tetrahydro-2-methyl- 1,5-benzorhiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 3-ch1oropropionyl chloride for the chloroacetyl chloride in part (B), 5-(3-piperidino propionyl)-2,3,4,5-tetrahydro 2 methyl-1,5-benzothiazepine, hydrochloride is obtained.

EXAMPLE 9 5 -pi peridinoacetyl-2,3,4,5 -tetrahydr0-1 ,5 benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-1,5-benzothiazepin- 4-one for the benzothiazepinone in part (A), 5-piperidinoacetyl-2,3,4,5-tetrahydro-1,5-benzothiazepine, hydrochloride is obtained.

EXAMPLE 10 S-piperidinoacetyl-2,3,4,5-tetrahydro-Z-ethyl-l,5-

benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-2-ethyl-1,5-benzo- 5 thiazepin-4-one for the benzothiazepine in part (A), 5- piperidinoacetyl 2,3,4,5 tetrahydro-Z-ethyl-1,5-benzethiazepine, hydrochloride is obtained.

EXAMPLE ll 5 -piper1'din0acetyl-2,3,4,5 -tetrahydr-3-mezhyl-1 ,5 benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-3-methyl-l,S-benzothiazepin-4-one for the benzothiazepinone in part (A), S-piperidinoacetyl-Z,3,4,5 tetrahydro 3 methyl-1,5- benzothiazepine, hydrochloride is obtained.

EXAMPLE l2 5-piperidinoacelyl-2,3,4,5-tetrahydro-2,3-dimethyl- 1,5-benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-2,3-dimethyl-1,5- benzothiazepin-l-one for the benzothiazepinone in part (A), 5 piperidinoacetyl-2,3,4,5-tetrahydro-2,3-dimethyl- 1,5-benzothiazepine, hydrochloride is obtained.

EXAMPLE 13 S-piperidz'noaceZyZ-Z,3,4,S-tetrahydro-Z-benzyl- 1,5-benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-2-benzyl 1,5-benzethiazepinl-one for the benzothiazepinone in part (A), 5 piperidinoacetyl-Z-benzyl 2,3,4,5 benzothiazepine, hydrochloride is obtained.

EXAMPLE 14 S-piperidinoacetyl-2,3,4,5-tetrahydro-2- (p-chlorobenzyl) -1,5-benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-2-(p-chlorobenzyl)- 1,5-benzothiazepin-4-one for the benzothiazepinone in part (A), 4-piperidinoacetyl-2,3,4,5-tetrahydro-2-(p-chlorobenzyl)-1,5-benzothiazepine, hydrochloride.

EXAMPLE l5 5-piperidinoacelyl-2,3,4,5-tetrahydr0-2-methyl-7- chloro-I,5-benzothiazepine, hydrochloride EXAMPLE 16 5-piperidinoacetyl-2,3,4,S-tetrahydro-Z-methyl-7- methoxy-I,S-benZothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-2-methyl-7-metl1- oxy-1,5-benzothiazepin-4-one for the benzothiazepinone in part (A), 5-piperidinoacety1 2,3,4,5-tetrahydro-2- methyl 7 methoxy 1,5 benzothiazepine, hydrochloride is obtained.

EXAMPLE 17 5-piperz'dinoacetyl-2,3,4,5-tetrahydro-Z,7-dimethyl- 1,5-benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of 2,3-dihydro-2,7dimethyl-1,5- benzothiazepin-4-one for the benzothiazepinone in part (A), 5-piperidinoacetyl 2,3,4,S-tetrahydro-2,7-dimethyl- 1,5-benzothiazepine, hydrochloride is obtained.

6 EXAMPLE 1s S-piperidinoacetyl-2,3,4,5-tetrahydro-2-methyl-7- trifluoromezhyl) -1,5-benzothiazepine, hydrochloride (A) Preparation of Z-amino-4-trifluoromethylthiophenol, hydrochloride A suspension of 200 g. of the zinc salt of 2-amino-4- trifluoromethylthiophenol [C.A., 47, 4769 g., J. Gen. Chem., 22, 2209 (1952)] in 400 ml. of water is treated with 200 ml. of conc. hydrochloric acid and the resulting mixture stirred and heated to The starting material dissolves and the hot solution is then treated with an additional 200 ml. of cone. hydrochloric acid. The hydrochloride salt separates as a gray precipitate. After cooling overnight, the solid is filtered and the filter-cake pressed to remove mother liquor and the former material suspended in 400 ml. of ether and cooled. The light gray solid is filtered, washed with ether and dried in a desiccator over potassium hydroxide pellets; M.P. 198-199.

(B) Preparation of 2-amino-4-trifluoromethylthiophenol As suspension of 140.0 g. (0.61 mole) of the above hydrochloride in 200 ml. of water is treated with a solution of 25.0 g. (0.6 mole) of sodium hydroxide in ml. of water. The liberated base is extracted several times and the combined extracts dried over magnesium sulfate. After filtration, the filtrate is concentrated and the residue fractionated to give a colorless liquid; B.P. 55-62 (0.2 mm.).

(C) Preparation of 2,3-dihydro-2-methyl-7-trifluoromethyl-1,5-benzothiazepin-4-one A mixture of 89.8 g. of the thiophenol from part (B) and 43.0 g. of crotonic acid is heated at -195 for thirty minutes. Water (6.5 ml.) is collected during this period. The product begins to crystallize from the mixture after about twenty minutes. The reaction mixture rapidly crystallizes on cooling. This material is pulverized and digested in 300 ml. of hot absolute alcohol and cooled. The colorless product is filtered and dried; M.P. 203204.

(D) Preparation of 5-piperidinoacetyl-2,3,4,5-tetrahydro- 2 methyl 7 (trifluoromethyl) 1,5 benzothiazepine, hydrochloride Following the procedure of Example 1 but substituting an equivalent amount of material from part (C) for the 'benzothiazepinone in part (A), 5-piperidinoacetyl-2,3,4,5- tetrahydro-2-methyl-7-(trifluoromethyl) 1,5 benzothiazepine, hydrochloride is obtained.

This invention may be variously otherwise embodied within the scope of the appended claims.

What is claimed is:

1. A compound selected from the group consisting of bases of the formula and pharmaceutically-acceptable acid-addition salts thereof, wherein X is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, nitro, halo and trifluoromethyl; R is selected from the group consisting of hydrogen and lower alkyl; R is selected from the group consisting of hydrogen, lower alkyl and X-substituted phenyl lower alkyl; A is lower alkylene; and NB is a basic nitrogen-containing radical of less than twelve carbon atoms selected from the group consisting of amino, (lower alkyl)amino, di(lower alkyl)amino, (hydroxy-lower alkyl)amino, di(hydroxy-lower alkyl)amino, phenyl- (lower alkyl) amino, N-(lower alkyl)-N-phenylflower alkyl)amino, piperidino, (lower alkyl)piperidino, (lower alkoxy)piperidino, homopiperidino, pyrrolidino, (lower alkyl)pyrro]idino, di(lower al-kyDpyrrolidino, (lower alkoxy)pyrrolidino, morpholino, (lower alkyl)morpholino, di(lower alkyl)morpholino, (lower alkoxy) morpholino, thiamorpholino, (lower alkyl)thiamorpholino, di(lower alkyDthiamorpholino, (lower alkoxy)thiamorpholino, piperazino, (lower alkyDpiperaZino, di(lower alkyDpiperazino, (lower alkoxy)piperazino, N -(hydroxylower alkyl)piperazino, N -(lower alkanoyloXy-lower alkyl)piperazino and homopiperazino.

2. 5 di(lower alkyl)amino(lower alkanoyl) 2,3,4,5- tetrahydro-Z-methyl-1,5-benzothiazepine.

3. A pharmaceutically-acceptable acid-addition salt of the compound of claim 2.

4. A pharmaceutically-acceptable acid-addition salt of 5 piperidinoacetyl 2,3,4,5 tetrahydro 2 methyl 1,5- benzothiazepine.

5. A pharmaceutically-acceptable acid-addition salt of 5 (N methylpiperazinoacetyl) 2,3,4,5 tetrahydro 2- methyl-1,5-benzothiazepine.

6. A compound of the formula wherein X is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, nitro, halo and trifluoromethyl; R is selected from the group consisting of hydrogen and lower alkyl; R is selected from the group consisting of hydrogen, lower alkyl and X-substituted phenyl lower alkyl and A is lower alkylene.

7. S-(chloro-lower alkanoyl) 2,3,4,5 tetrahydro-Z- methyl-1,5-benzothiazepine.

8. 5-chloroacetyl 2,3,4,5 tetrahydro 2 methyl-1,5- benzothiazepine.

9. A compound of the formula:

wherein R is selected from the group consisting of hydrogen and lower alkyl.

References Cited UNITED STATES PATENTS 3,029,251 4/1962 Fancher etal; 260-327 OTHER REFERENCES 'Hromat-ka et 21.: Monatsh. Fur Chemie, vol. 88 (1957), pp. 64-71.

I. A. PATTEN, Primary Examiner.

N. S. RIZZO, Examiner. 

1. A COMPOUND SELECTED FROM THE GROUP CONSISTING OF BASES OF THE FORMULA
 5. A PHARMACEUTICALLY-ACCEPTABLE ACID-ADDITION SALT OF 5-(N4-METHYLPIPERAZINOACETYL) - 2,3,4,5-TETRAHYDRO-2METHYL-1,5-BENZOTHIAZEPINE. 